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Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2101-2113 doi: 10.1007/s11705-023-2361-5

Abstract: mechanism showed that compound A17 induced an excessive accumulation and production of reactiveoxygen species in bacteria and damaged the cell membrane integrity to kill bacteria.

Keywords： ursolic acid     antibacterial activities     reactive oxygen species     apoptosis    

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NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 1-7 doi: 10.1007/s11684-009-0018-5

Abstract: Reactive oxygen species (ROS) are small molecule metabolites of oxygen that are prone to participatePhysiologically, ROS are involved in many signaling cascades that contribute to normal processes.One classical example is that ROS derived from the NADPH oxidase and released in neurotrophils are ableExcessive ROS, however, contribute to pathogenesis of various human diseases including cancer, aging,As signaling messengers, ROS are able to oxidize many targets such as DNA, proteins and lipids, which

Keywords： free radicals     tumor     phox     cell proliferation     cancer therapy    

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Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract: Reactive oxygen species (ROS) was analyzed by flow cytometry.Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation.The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-inducedIn conclusion, our results revealed a functional link between intracellular ROS generation and cisplatin-induced

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

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Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 697-706 doi: 10.1007/s11684-018-0655-7

Abstract: This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactiveoxygen species (ROS) and further explored the underlying molecular mechanisms.We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aorticResveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROSTaken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy

Keywords： resveratrol     reactive oxygen species     AMPK     mTOR     autophagy    

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Persistent free radicals in humin under redox conditions and their impact in transforming polycyclic aromatic hydrocarbons

Hanzhong Jia, Yafang Shi, Xiaofeng Nie, Song Zhao, Tiecheng Wang, Virender K. Sharma

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 4, doi: 10.1007/s11783-020-1252-y

Abstract: . • The newly produced PFRs readily release electrons to oxygen and generate ROS. • PFR-induced ROS mediateprocess, the HM-associated “unstable” free radicals released an electron to O2, inducing the formation of reactiveoxygen species (ROS, i.e., •OH and •O2−).The generated ROS promoted the degradation of polycyclic aromatic hydrocarbons based on the radical quenching

Keywords： Humic substance     Polycyclic aromatic hydrocarbons (PAHs)     Persistent free radicals (PFRs)     Redox     Reactiveoxygen species (ROS)    

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concentrations of ionic silver promote the proliferation of human keratinocytes by inducing the production of reactiveoxygen species

Xiaodong Duan, Daizhi Peng, Yilan Zhang, Yalan Huang, Xiao Liu, Ruifu Li, Xin Zhou, Jing Liu

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 289-300 doi: 10.1007/s11684-017-0550-7

Abstract: /sup>) on the proliferation of human skin keratinocytes (HaCaT) and the production of intracellular reactiveoxygen species (ROS).After treating HaCaT cells with Ag+and/or the active oxygen scavenger N-acetyl cysteine (NAC), cell proliferation and intracellular ROS generation were assessed using CCK-8 reagent and DCFH-DAIntracellular ROS generation also significantly increased for 5–60 min after exposure to Ag

Keywords： ionic silver     human keratinocyte     cell proliferation     reactive oxygen species     active oxygen scavenger     NAC    

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Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 327-332 doi: 10.1007/s11684-007-0063-x

Abstract: Reactive oxygen species (ROS) are important mediators in apoptosis induced by various stimuli, whichIn this study, we investigated the relationship between ROS and the levels of DNA damage induced by seleniteThe levels of ROS induced by selenite were measured by 2′, 7′-dichlorofluorescein diacetate (DCFH-DA)N-acetylcysteine (NAC), a known antioxidant, increased cell viability and decreased ROS generation.These results revealed that ROS might play an important role in selenite-induced DNA damage that can

Keywords： NAC     N-acetylcysteine     DNA     fluorescence     relationship    

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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: decreased mitochondrial complex I activities, lower mitochondrial aerobic respiration, and a high level of ROS

Keywords： TRMT2B     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygenspecies    

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Visible light induces bacteria to produce superoxide for manganese oxidation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1619-y

Abstract:

● Term of manganese-oxidizing microorganisms should be reconsidered.

Keywords： Mn(II) oxidation     Manganese-oxidizing bacteria     Reactive oxygen species     Mn(III/IV) oxides    

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INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 3,   Pages 447-459 doi: 10.15302/J-FASE-2021399

Abstract: Hyphae treated with these compounds produced more abnormal branches and accumulated reactive oxygen species

Keywords： fennel and tobacco rotation     infection behavior     Phytophthora nicotianae     reactive oxygen species    

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Biotoxicity evaluation of zinc oxide nanoparticles on bacterial performance of activated sludge at COD, nitrogen, and phosphorus reduction

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1453-z

Abstract:

• ZnO-NP disrupted metabolic/catabolic balance of bacteria by affecting DHA activity.

Keywords： Granular sludge     Biotoxicity     Reactive oxygen species     Extracellular polymeric substances    

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Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review

Virender K. Sharma, Xin Yu, Thomas J. McDonald, Chetan Jinadatha, Dionysios D. Dionysiou, Mingbao Feng

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1122-7

Abstract:

Antibiotic-resistant bacteria and antibiotic resistance genes are in water bodies.

UV/chlorination method is better to remove ARGs than UV or chlorination alone.

Research on UV/hydrogen peroxide to eliminate ARGs is forthcoming.

UV-based photocatalytic processes are effective to degrade ARGs.

Keywords： Antibiotic resistance bacteria     Advanced oxidation processes     Disinfection     Reactive chlorine species     Sulfateradicals     Reactive oxygen species    

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Cooperative effect between copper species and oxygen vacancy in CeZrCuO catalysts for carbon monoxide

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1524-1536 doi: 10.1007/s11705-021-2106-2

Abstract: Thus, the number of oxygen vacancies caused by the Cu2+ entering the lattice (e.g., Cu2+–□–Ce4+; □: oxygen vacancy), and the amount of reducible copper species caused byCatalytic CO oxidation tests indicated that the oxygen vacancy and the reducible copper species wereThus, the samples x = 0.1 and 0.3, which possessed the most oxygen vacancy or reducible copperspecies, showed the best activity for CO oxidation, with full CO conversion obtained at 110 °C.

Keywords： Ce–Zr–Cu–O     CO oxidation     reducible copper species     oxygen vacancy     cooperative effect    

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Review on design and evaluation of environmental photocatalysts

Xin Li, Jun Xie, Chuanjia Jiang, Jiaguo Yu, Pengyi Zhang

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 5, doi: 10.1007/s11783-018-1076-1

Abstract: itemcontent>

The mechanism aspects, including O2 reduction, reactiveoxidation species and key intermediates were also addressed.

Keywords： Photocatalytic degradation     Environmental remediation     Charge carrier dynamics     Reactive oxygen species    

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Light-induced variation in environmentally persistent free radicals and the generation of reactive radicalspecies in humic substances

Yafang Shi, Yunchao Dai, Ziwen Liu, Xiaofeng Nie, Song Zhao, Chi Zhang, Hanzhong Jia

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 6, doi: 10.1007/s11783-020-1285-2

Abstract: . • The “unstable” free radicals induced the formation of reactive radical species. • Reactive radicalsSignificant positive correlations were observed between the concentrations of EPFRs and reactive radicalspecies (R2 = 0.65–0.98, p<0.05), which suggested that the newly produced EPFRs contributed to the formationof reactive radical species.Our findings indicate that under the irradiation humic substances are likely to be more toxic and reactive

Keywords： Peat     Humic substances     Environmentally persistent free radicals     Light irradiation     Reactive radical species    

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Title Author Date Type Operation

Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated

Journal Article

NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Journal Article

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Journal Article

Persistent free radicals in humin under redox conditions and their impact in transforming polycyclic aromatic hydrocarbons

Hanzhong Jia, Yafang Shi, Xiaofeng Nie, Song Zhao, Tiecheng Wang, Virender K. Sharma

Journal Article

concentrations of ionic silver promote the proliferation of human keratinocytes by inducing the production of reactiveoxygen species

Xiaodong Duan, Daizhi Peng, Yilan Zhang, Yalan Huang, Xiao Liu, Ruifu Li, Xin Zhou, Jing Liu

Journal Article

Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Journal Article

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Visible light induces bacteria to produce superoxide for manganese oxidation

Journal Article

INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE

Journal Article

Biotoxicity evaluation of zinc oxide nanoparticles on bacterial performance of activated sludge at COD, nitrogen, and phosphorus reduction

Journal Article

Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review

Virender K. Sharma, Xin Yu, Thomas J. McDonald, Chetan Jinadatha, Dionysios D. Dionysiou, Mingbao Feng

Journal Article

Cooperative effect between copper species and oxygen vacancy in CeZrCuO catalysts for carbon monoxide

Journal Article

Review on design and evaluation of environmental photocatalysts

Xin Li, Jun Xie, Chuanjia Jiang, Jiaguo Yu, Pengyi Zhang

Journal Article

Light-induced variation in environmentally persistent free radicals and the generation of reactive radicalspecies in humic substances

Yafang Shi, Yunchao Dai, Ziwen Liu, Xiaofeng Nie, Song Zhao, Chi Zhang, Hanzhong Jia

Journal Article